Blar i forfatter "Bøgwald, Jarl"

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    • Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives. 

      Tafalla, C; Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Vaccination is the most adequate method to control infectious diseases that threaten the aquaculture industry worldwide. Unfortunately, vaccines are usually not able to confer protection on their own; especially those vaccines based on recombinant antigens or inactivated pathogens. Therefore, the use of adjuvants or immunostimulants is often necessary to increase the vaccine efficacy. Traditional ...

    • Anatomical distribution of scavenger endothelial cells in bony fishes (Osteichthyes) 

      Seternes, Tore; Poppe, Trygve T; Bøgwald, Jarl; Lynghammar, Arve; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-28)
      The scavenger endothelial cells (SECs) of vertebrates are an important class of endocytic cells responsible for clearance of foreign and physiological waste macromolecules, partitioning in the immune system, functioning as a cellular powerplant by producing high energy metabolites like lactate and acetate. All animal phyla possess SECs, but the tissue localization of SECs has only been investigated ...

    • Eomesodermin of Atlantic Salmon: An Important Regulator of Cytolytic Gene and Interferon Gamma Expression in Spleen Lymphocytes 

      Kumari, Jaya; Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Eomesodermin (Eomes), a T-bet homologue expressed in activated CD8+T cells was recently proposed to act as a master regulator of cytotoxic CD8+ T cell effector function and offers an exciting avenue for future exploration. Here, we have identified and characterized the full-length Atlantic salmon Eomes cDNA (2477 bp). Promoter analysis of the salmon Eomes showed the presence of important putative ...

    • Innate Immunity 

      Dalmo, Roy Ambli; Bøgwald, Jarl (Chapter; Bokkapittel, 2022-03-13)
      Research on the innate immunity has accelerated over the last decades. The main reason for this has been the discovery of receptors recognizing danger molecules from pathogens. This has been facilitated through genome and transcriptome sequencing of different fish species. Also, endogenous host molecules from sterile physiological insults may also bind to certain receptors and induce immunological ...

    • Overexpression of T-bet, GATA-3 and TGF-ß induces IFN-γ, IL-4/13A, and IL-17A expression in Atlantic salmon 

      Slettjord, Tiril Hoffstrøm; Sekkenes, Hege J.; Chi, Heng; Bøgwald, Jarl; Swain, Trilochan; Dalmo, Roy Ambli; Swain, Jaya Kumari (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-20)
      The overexpression of <i>GATA-3, T-bet</i> and <i>TGF-ß</i> may theoretically induce <i>IL-4/A, IFN-γ</i> and <i>IL-17A</i> expression, respectively. Whether this also applies to fish is not yet known. The plasmid vectors encoding reporter gene (RFP)-tagged <i>T-bet, GATA-3</i> and <i>TGF-ß</i> were used as overexpression tools, transfected into cells or injected intramuscularly to monitor the ...

    • Protection of teleost fish against infectious diseases through oral administration of vaccines: Update 2021 

      Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-10)
      Immersion and intraperitoneal injection are the two most common methods used for the vaccination of fish. Because both methods require that fish are handled and thereby stressed, oral administration of vaccines as feed supplements is desirable. In addition, in terms of revaccination (boosting) of adult fish held in net pens, oral administration of vaccines is probably the only feasible method to ...

    • Review on Immersion Vaccines for Fish: An Update 2019 

      Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-29)
      Immersion vaccines are used for a variety of aquacultured fish to protect against infectious diseases caused by bacteria and viruses. During immersion vaccination the antigens are taken up by the skin, gills or gut and processed by the immune system, where the resulting response may lead to protection. The lack of classical secondary responses following repeated immersion vaccination may partly be ...

    • Scavenger endothelial cells of fish, a review 

      Seternes, Tore; Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-17)
      The definition of scavenger endothelial cells (SEC) is exclusively based on functional and structural characteristics. The following characteristics are common hallmarks for the vertebrate SEC: (a) All vertebrates examined are furnished with a population of special SEC that plays a role in the catabolism of physiologic and non-physiologic soluble waste macromolecules. (b) From the ligands that are ...

    • Th17 master transcription factors RORα and RORγ regulate the expression of IL-17C, IL-17D and IL-17F in Cynoglossus semilaevis 

      Chi, Heng; Bøgwald, Jarl; Dalmo, Roy Ambli; Zhang, Wenjie; Hu, Yong-hua (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-10)
      The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. In this study, we examined the regulatory properties of RORα (CsRORα) and RORγ (CsRORγ) in tongue sole (Cynoglossus semilaevis). CsRORα and CsRORγ expression was detected in major lymphoid organs and altered to significant extents after bacterial and viral infection. CsRORα ...

    • Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection 

      Kumari, Jaya; Zhang, Zuobing; Swain, Trilochan; Chi, Heng; Niu, Cuijuan; Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-06)
      The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive immune responses in higher vertebrates. In the present study, we have identified and characterized the full-length Atlantic salmon T-bet cDNA (3502 ...

    • Transgene and immune gene expression following intramuscular injection of Atlantic salmon (Salmo salar L.) with DNA-releasing PLGA nano- and microparticles 

      Hølvold, Linn Benjaminsen; Fredriksen, Børge Nilsen; Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The use of poly-(D,L-lactic-co-glycolic) acid (PLGA) particles as carriers for DNA delivery has received considerable attention in mammalian studies. DNA vaccination of fish has been shown to elicit durable transgene expression, but no reports exist on intramuscular administration of PLGA-encapsulated plasmid DNA (pDNA). We injected Atlantic salmon (Salmo salar L.) intramuscularly with a plasmid ...